One-Pot Synthesis of Pyrazolyl-Containing α-Aminophosphonates

Abstract

A series of novel pyrazolyl-containing α-aminophosphonates were synthesized by one-pot reaction from 4-formylpyrazole, substituted aromatic amines, and dialkylphosphites. The synthesized compounds were characterized by elemental analysis, ¹H NMR, and IR spectroscopy. Single-crystal X-ray diffraction data of compounds 4a and 5b were obtained, and some of these compounds showed inhibitory effect on eggplant-infecting Botrytis cinerea.

Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements for the following free supplemental resource: Tables S1-S4. Figures S1 and S2 .cif files.

GRAPHICAL ABSTRACT

Keywords:

• Pyrazole
• α-aminophosphite
• synthesis
• crystal structure

Acknowledgments

The authors are grateful for the support of Ms. Hua Yang and Ms. Yuan-Yu Cuion on the biological activity texts of this work. This work was supported by the National Natural Science Foundation of China (grant no. 20462006) and the Xinjiang Key Laboratory of Plant Resources and Natural Products Chemistry.