Abstract
We have synthesized a series of novel 2-(6,14-endo-ethenotetrahydrothebaine-7α-yl)-5-N-arylamino-1,3,4-thiadiazoles (5a–n) as potential narcotic analgesics, which are analogs of morphine. The synthesized compounds exhibit rigid morphine structures, including a 6,14-endo-entheno bridge and a 5-N-arylamino-1,3,4-thiadiazol-2-yl group at C-7 position that adopted S-configuration. The structures and stereochemistry of the compounds were completely assigned using one- and two-dimensional NMR experiments (1H NMR, APT, COSY, NOESY, HMQC, and HMBC), FTIR, and high-resolution mass spectral (HRMS) data.
Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.
GRAPHICAL ABSTRACT
![](/cms/asset/36b5633f-e539-49ba-9c5e-fc7b7d66d938/gpss_a_649499_o_uf0001.gif)
Keywords:
Acknowledgments
The authors gratefully acknowledge financial support from the Scientific and Technical Research Council of Turkey (TUBITAK, Project No. 107T676). We also thank the Turkish Grain Board (TMO) for the supply of thebaine.