Dialkyl (Alkylene) Dithiophosphate Adducts of Anhydrous Stannous Chloride: Synthesis, Characterization, and Biological Activities

Abstract

Dialkyl (alkylene) dithiophosphate adducts of stannous chloride were synthesized by the reaction of anhydrous tin(II) chloride (SnCl₂) and dialkyl (alkylene) dithiophosphoric acid in a 1:1 molar ratio, under anhydrous reaction conditions, below 5 °C in a closed vessel. The newly synthesized adducts were characterized by physicochemical and spectroscopic techniques [FT-IR, NMR (¹H, ³¹P, and ¹¹⁹Sn), and mass spectrometry]. Coordination modalities have indicated a donor–acceptor interaction between sulfur and tin(II) moieties, where tin(II) acts as a Lewis acid. The adducts were found to have significant antibacterial activity against Escherichia coli and Pseudomonas aeruginosa, and antifungal activity against Aspergillus niger and Candida albicans.

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GRAPHICAL ABSTRACT

Keywords:

• Adducts
• anhydrous stannous chloride
• dialkyl (alkylene) dithiophosphoric acid
• antifungal activity
• antimicrobial activity

Acknowledgments

The authors are highly thankful to the Department of Chemistry, University of Rajasthan, Jaipur, India for providing the necessary facilities for experimentation. They express their sincere thanks to Defence Institute of Bio-Energy Research, Haldwani, India to support this study, and Institute of Microbial Technology, Chandigarh, India for providing the microbial culture. One of the authors, Mohammed Mohsin is also thankful to Council of Scientific and Industrial Research (CSIR), New Delhi, India for providing the Research Fellowship for his research activities. This article is dedicated to Late Dr. P. N. Nagar, Professor, Department of Chemistry, U.O.R. Jaipur.