Rapid and Convenient Method for the Synthesis of Symmetrical Disulfides

Abstract

We present here the results on the use of 1,3,5-triazo-2,4,6-triphosphorine-2,2,4,4,6,6-hexachloride as an efficient promoter in the conversion of thiols to the corresponding symmetrical disulfides under solvent-free conditions. Aromatic thiols bearing electron donating and electron withdrawing groups, heteroaromatic, and alkyl thiols reacted efficiently to afford excellent yields of disulfides in short reaction times after easy work-up. Different functional groups including carboxyl, methoxy, methylthio, and halogen are tolerated.

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GRAPHICAL ABSTRACT

Keywords:

• Thiols
• disulfides
• solvent-free conditions
• oxidative conversion
• 1,3,5-triazo-2,4,6-triphosphorine-2,2,4,4,6,6-hexachloride (TAPC)