Synthesis of Bis(2-Pyridylphosphino)Alkanes in Superbasic Medium and Their Hydroxymethyl Derivatives

Abstract

Novel P-H-diphosphinoalkanes with pyridyl substituents at the phosphorus atoms have been obtained in good or moderate yields by the interaction of primary 2-pyridyl-phosphine with dichloroalkanes in superbasic medium. The formation of novel 1-(2-pyridyl)-1-phosphacyclopentane together with bis(2-pyridylphosphino)butane was observed as the result of the interaction of 2-pyridylphosphine and 1,4-dichlorobutane under the same reaction conditions. The reaction of the bis(2-pyridylphosphino)alkanes thus obtained with formaldehyde leads to the formation of the corresponding hydroxymethyl derivatives.

GRAPHICAL ABSTRACT

Keywords:

• P-H-diphosphinoalkanes
• superbasic medium
• bis(hydroxymethyl(2-pyridyl)- phosphino)alkanes

Acknowledgments

This work was supported by RFBR (No. 10-03-00380-а, 11-03-12152-ofi_m, 12-03-97083-r_a), by the President's of RF Grant for the support of leading scientific schools (No. NSh-6667.2012.3), as well as by the Ministry of Science and Education of RF (SC No 02.740.11.063).