Application of “Click” Cycloaddition for Synthesis of New Sulfur-Containing Oligomeric System

Abstract

The efficient synthesis of new sulfur-containing macrocycles via “click”-type alkyne–azide cycloaddition was described. Preliminarily, under aqueous conditions (water–methanol) using CuSO₄/sodium ascorbate as a source of Cu(I), the yields of the products were very poor. Using the Cu(I) in nonaqueous solution (MeCN), the yields of the products grow significantly (approx. 50%).

GRAPHICAL ABSTRACT

Keywords:

• Macrocyclic systems
• click chemistry
• 1,3-dipolar cycloaddition
• sulfur oligomers

Acknowledgments

Authors acknowledge financial support from National Science Center (NCN, Grant No. 2011/01/B/ST5/ 06613).