Trimethylarsonium-Based Cationic Phospholipids for Gene Delivery

Abstract

Lipophosphoramide-based cationic lipids are a class of synthetic vectors used for gene delivery that can be produced in multigram scale. The use of trimethylarsonium moiety as a cationic polar head was beneficial to produce efficient gene delivery vectors for in vivo applications. Moreover, this type of cationic lipid can also exhibit some bactericidal effects.

GRAPHICAL ABSTRACT

Keywords:

• Phospholipids
• phosphoramides
• arsonium
• gene delivery
• liposomes
• cationic lipids

Acknowledgments

The authors thank “Structure Fédérative de Recherche de Brest” (SFR ScInBioS), “Association Française contre les Myopathies” (AFM, Evry, France), “Vaincre La Mucoviscidose” (Paris, France), and “Association de transfusion sanguine et de biogénétique Gaétan Saleün” (Brest, France).