Synthesis and Characterization of Nitrogen Heterocyclic Derivatives Containing Sulfur–Ether and Schiff Base

Jinyun Zheng Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China

Yujian Yu Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China

Xiaomin Zhen Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China

Erbing Yang Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China

Yufen Zhao Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China; Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, China; Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, China

Abstract

A series of new nitrogen heterocyclic compounds containing sulfur–ether (8a–8f) and Schiff-base (9a–9q) functionalities were synthesized by the reaction of the pharmaceutical lead compound containing both benzimidazole and 1,2,4-triazole rings. The compounds were characterized by ¹H NMR, ¹³C NMR, FT-IR, HR-MS, and ESI-MS.

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[Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional figures.]

Acknowledgments

The authors would like to thank the National Natural Science Foundation Committee of China for financial support to this work (No. 20732004).

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Synthesis and Characterization of Nitrogen Heterocyclic Derivatives Containing Sulfur–Ether and Schiff Base

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Synthesis and Characterization of Nitrogen Heterocyclic Derivatives Containing Sulfur–Ether and Schiff Base

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