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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 188, 2013 - Issue 11
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Original Articles

Synthesis and Antioxidant Activity Evaluation of Novel 5,7-dimethyl-3H-Thiazolo[4,5-B]Pyridines

Taras I. Chaban Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
,
Volodymyr V. Ogurtsov Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
,
Ihor G. Chaban Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
,
Olena V. Klenina Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
&
Josef D. Komarytsia Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Pages 1611-1620 | Received 15 Nov 2012, Accepted 15 Feb 2013, Published online: 20 Sep 2013
 
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Abstract

5,7-Dimethyl-3H-thiazolo[4,5-b]pyridine-2-one was obtained under the reaction of 4-iminothiazolidin-2-one with acetylacetone. Further structural modifications include the introduction of diversity at the N3 and C6 positions. The antioxidant activity of the synthesized compounds was evaluated in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.

[Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the following free supplemental files: Additional figures]

GRAPHICAL ABSTRACT

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Related Research Data

Synthesis and cytotoxicity of new 2-oxo-7-phenyl-2,3-dihydrothiazolo[4,5- b ]pyridine-5-carboxylic acid amides
Source: Informa UK Limited
Crystal structure of 2-tert-butyl-1,3-thiazolo[4,5-b]pyridine
Source: International Union of Crystallography (IUCr)
Crystal structure of 2-(2-methylphenyl)-1,3-thiazolo[4,5- ]pyridine
Source: (:unav)
Synthesis, coordination properties and DFT studies of novel trans-disubstituted hexaaza-macrocycles containing pyridine and/or ethyldioxolane arms
Source: Informa UK Limited
Synthesis and cytotoxicity of new thiazolo[4,5-b]pyridine-2(3H)-one derivatives based on α,β-unsaturated ketones and α-ketoacids
Source: Springer Science and Business Media LLC

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