Synthesis of 3-Fluoro-2-(Diethoxyphosphoryl) Imidazo[1,2-A]Pyrimidine

Abstract

The first representative of 3-fluoro-2-(dialkoxyphosphoryl)imidazo[1,2-a]pyrimidi nes has been synthesized by the reaction of N-(pyrimidin-2-yl)-2,2,2-trifluoroacetimidoyl chloride with triethyl phosphite.

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GRAPHICAL ABSTRACT

Keywords:

• Trifluoroacetimidoyl chloride
• triethyl phosphite
• heterylphosphonate
• cyclodefluorination

Acknowledgments

This research was supported by the Russian Fond of Basic Research (Grants 11-03-00496-а, 11-03-00480-a, 12-03-00828-a) and program of Presidium of Russian Academy of Sciences “Development of the methodology of organic synthesis and creating of compounds with applied properties”.