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Abstract
This review describes the reactions of α/β-mercaptoalkanoic acids as building blocks for the synthesis of heterosteroids, polyfunctional heterocycles with pharmacological interest. Annelated heterocycles have been prepared by the cyclocondensation reaction of α- and β-mercaptoalkanoic acids with carbonyl compounds. This reaction takes place by nucleophilic addition, followed by cyclization with elimination of water. The main objective of this survey is to provide a comprehensive account of this reaction type in building various heterocycles, and examining their potential in developing better chemotherapeutic agents.
GRAPHICAL ABSTRACT
Acknowledgments
Dedicated to Dr. R. Gopalan on the occasion of his 70th birthday.
The author thanks Dr. S. R. Ramadas, Retd. Professor of IIT, Chennai; Dr. C. S. Rao, Tech. Advisor, Laurus Labs Pvt. Ltd., Hyderabad; and Dr. C. R. V. Rao, Former Vice Chancellor of Vikrama Simhapuri University, Andhra Pradesh, for their help and constant encouragement.