An Efficient One-Pot Synthesis of New 2- Thioxo and 2-oxo-pyrimidine-5-carbonitriles in Ball-Milling Under Solvent-Free and Catalyst-Free Conditions

Abstract

Various 2-thioxo and 2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitriles were synthesized in very high yields in 40 min through a direct condensation of an equimolar amount of an aldehyde, malononitrile, and thiourea/urea under ball mill solvent-free and catalyst-free conditions.

GRAPHICAL ABSTRACT

Keywords:

• Ball milling solvent-free reaction
• catalyst-free
• thioxo-pyrimidine
• oxo-pyrimidine

Acknowledgments

The authors are very much thankful to King Abdulaziz City for Science and Technology (KACST) and King Saud University (KSU) for recording the analysis of synthesized compounds.