Synthesis of Novel 4H-Chromenes Containing a Pyrimidine-2-Thione Function in the Presence of Fe₃O₄ Magnetic Nanoparticles and Study of Their Antioxidant Activity

Mehdi KhoobiDepartment of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran14176, Iran

Ali RamazaniDepartment of Chemistry, University of Zanjan, P.O. Box 45195-313, Zanjan, IranCorrespondence[email protected] [email protected]

Zahra HojjatiDepartment of Chemistry, University of Zanjan, P.O. Box 45195-313, Zanjan, Iran

Raheleh ShakeriInstitute of Biochemistry and Biophysics (I.B.B.), University of Tehran, P.O. Box 13145-1384, Tehran, I.R. Iran

Mehdi KhoshneviszadehDepartment of Chemistry, University of Zanjan, P.O. Box 45195-313, Zanjan, Iran;Medicinal & Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz71345, Iran

Susan Kaboudanian ArdestaniInstitute of Biochemistry and Biophysics (I.B.B.), University of Tehran, P.O. Box 13145-1384, Tehran, I.R. Iran

Abbas ShafieeDepartment of Chemistry, University of Zanjan, P.O. Box 45195-313, Zanjan, Iran

Alireza ForoumadiDepartment of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran14176, Iran

Sang Woo JooSchool of Mechanical Engineering, Yeungnam University, Gyeongsan712-749, Republic of KoreaCorrespondence[email protected] [email protected]

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GRAPHICAL ABSTRACT

Abstract

The aim of the present work was to search for identification of novel reactive oxygen species (ROS) scavengers by testing new fused chromenopyrimidinethiones, which was synthesized using Fe₃O₄ nanoparticles. The new compounds were also tested for their cytotoxic activity. The obtained results showed that the incorporated pyrimidinethione moiety significantly increase antioxidant activity. In conclusion, the study of the pharmacological properties of the new chromenopyrimidinethiones allowed establishing new structure–activity relationships for splitting antioxidant and cytotoxic activity of these compounds.

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Synthesis of Novel 4H-Chromenes Containing a Pyrimidine-2-Thione Function in the Presence of Fe₃O₄ Magnetic Nanoparticles and Study of Their Antioxidant Activity

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Synthesis of Novel 4H-Chromenes Containing a Pyrimidine-2-Thione Function in the Presence of Fe3O4 Magnetic Nanoparticles and Study of Their Antioxidant Activity

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Synthesis of Novel 4H-Chromenes Containing a Pyrimidine-2-Thione Function in the Presence of Fe₃O₄ Magnetic Nanoparticles and Study of Their Antioxidant Activity