GRAPHICAL ABSTRACT
Abstract
The reaction of 6-amino-2-(prop-2-yn-1-ylsulfanyl)pyrimidin-4(1H)-one with various iodobenzenes in the presence of a Pd-Cu catalyst leads to the regioselective cyclization to 5-amino-3-benzyl-7H-[1,3]thiazolo[3,2-a]pyrimidin-7-ones. This one-pot procedure is very simple, and affords good-to-high yields.