Synthesis and Biological Evaluation of a Phosphonate Phosphoantigen Prodrug

Chia-Hung Christine HsiaoDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA

Xiaochen LinDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA

Rocky J. BarneyDepartment of Chemistry, University of Iowa, Iowa City, Iowa, USA;Department of Chemistry, Western Wyoming Community College, Rock Springs, Wyoming, USA

Rebekah R. ShippyDepartment of Chemistry, University of Iowa, Iowa City, Iowa, USA

Jin LiDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA

Olga VinogradovaDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA

David F. WiemerDepartment of Chemistry, University of Iowa, Iowa City, Iowa, USA;Department of Pharmacology, University of Iowa, Iowa City, Iowa, USA

Andrew J. WiemerDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USACorrespondence[email protected]

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GRAPHICAL ABSTRACT

Abstract

We have recently reported the synthesis of the first known phosphoantigen prodrug, and have demonstrated excellent gains in potency through delivery of the phosphoantigen to the intracellular domain of BTN3A1.

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Synthesis and Biological Evaluation of a Phosphonate Phosphoantigen Prodrug

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Synthesis and Biological Evaluation of a Phosphonate Phosphoantigen Prodrug

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