Synthesis and Bioactivity of Novel Phenothiazine-Based Thiazole Derivatives

GRAPHICAL ABSTRACT

Abstract

A series of phenothiazine-based thiazole derivatives were synthesized and evaluated for their cytotoxicity against three cancer cell lines A549, MCF-7, and HT29 by MTT assay. Among several thiazole derivatives, compound 3d against HT29 cells and 3g against MCF-7 cells are found to display good cytotoxicity. These compounds have also been tested for antifungal and antioxidant activity. Some of these compounds exhibited significant antifungal activity and compound 3j was found to exhibit almost equivalent antioxidant activity as that of BHT.

Keywords:

• Phenothiazine
• thiazole
• α-bromo ketone
• cytotoxicity
• antifungal