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Original Articles

New Amino-Bisphosphonate Building Blocks in the Synthesis of Bisphosphonic Derivatives Based on Lead Compounds

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Pages 1201-1212 | Received 08 Sep 2014, Accepted 20 Oct 2014, Published online: 25 Jul 2015
 

GRAPHICAL ABSTRACT

Abstract

A facile procedure for the synthesis of new aminobisphosphonate building blocks has been developed. The latter were used in the preparation of conjugates with ursolic, betulonic, betulinic, folic acids, and trolox—the promising antitumor agents.

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