GRAPHICAL ABSTRACT
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Abstract
The synthesis of phosphonium-boronate amino acid derivatives was achieved by quaternization of o-boronatophenylphosphine with iodo-amino acid derivatives. Preliminary radiolabelling studies demonstrate the facile 18F-fluoride trapping and the high stability of the trifluoroborato products in aqueous conditions, making these new compounds very promising for molecular imaging of peptides and proteins using PET.