A Facile One-Step Multi-Component Approach toward the Synthesis of 3-(2-Amino-4-Thiazolyl)Coumarins by using Trimethylsilyl Isothiocyanate and their Antioxidant and Anti-Inflammatory Activity

GRAPHICAL ABSTRACT

Abstract

A multi-component synthesis of 3-(2-amino-4-thiazolyl)coumarins has been reported from 3-(2-bromoacetyl)-2H-chromen-2-ones primary amines and using commercially available trimethylsilyl isothiocyanate. The structures of newly synthesized compounds were characterized by their analytical and spectral data. All the title compounds were screened for antioxidant and anti-inflammatory activity. Among the screened compounds, 4b exhibited highest free radical scavenging activity and also 4b was found to be effective in inhibiting the protein denaturation at all tested concentrations.

Keywords:

• Trimethylsilyl isothiocyanate
• coumarin
• multi-component reaction
• primary amines