User Friendly Synthesis of Vogel’S Silyl Sulfinate and its Application in Quantitative Gc–Ms Analysis

GRAPHICAL ABSTRACT

Abstract

The synthesis of trimethylsilyl 2-methylprop-2-ene-1-sulfinate (Vogel's silyl sulfinate) from methallyltrimethylsilane and SO₂ in the presence of Tf₂NTMS was developed. The title compound silylates carbohydrates and other polyhydroxylated compounds by producing SO₂ and isobutene as gaseous side products. This silylation procedure is perfectly suitable for derivatization and subsequent GC–MS quantitative analysis of ribose and malic acid as representatives of organic polyhydroxylated compounds.

Keywords:

• Trimethylsilyl 2-methylprop-2-ene-1-sulfinate
• silylation
• GC–MS derivatization
• ribose
• malic acid