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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 190, 2015 - Issue 11
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Original Articles

Synthesis, Crystal Structure, and Biological Activity of Some Novel Sulfoxide Compounds Containing 1,2,3-Thiadiazole Moiety

Li-Jing MinCollege of Life Science, Huzhou University, Huzhou, Zhejiang, China
,
Ming-Yan YangCollege of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China
,
Jin-Xia MuCollege of Quality & Safety Engineering, China Jiliang University, Hangzhou, Zhejiang, China
,
Zhao-Hui SunCollege of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China
,
Cheng-Xia TanCollege of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China
,
Jian-Quan WengCollege of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China
,
Xing-Hai LiuCollege of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou, Zhejiang, ChinaCorrespondence[email protected] [email protected]
&
Yong-Gang ZhangInstitute of Biology, Shandong Academy of Science, Jinan, China
 show all
Pages 1884-1892 | Received 05 Jan 2015, Accepted 17 Mar 2015, Published online: 02 Dec 2015
 
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GRAPHICAL ABSTRACT

Abstract

Some new sulfoxide compounds containing 1,2,3-thiadiazole moiety were synthesized from diethyl carbonate and hydrazine hydrate by multi-step reactions. Their structures were confirmed by NMR, MS, and elemental analysis. One of the title compounds, 5-(4-cyclopropyl-5-((3-fluorobenzyl)sulfinyl)-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole (C15H14FN5OS2), was structurally determined by a single crystal X-ray diffraction study. The biological activity of the title compound was determined, and the results showed that it displays moderate biological activities.

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