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Original Articles

Heterocyclic synthesis using the intramolecular Mannich cyclization reaction and enantiopure N-sulfinyl β-amino carbonyl compounds

Pages 297-304 | Received 27 May 2015, Accepted 10 Jun 2015, Published online: 06 Feb 2016
 

GRAPHICAL ABSTRACT

Abstract

This mini review summaries applications of N-sulfinyl imine derived β-amino carbonyl compounds, Mannich bases, for the asymmetric synthesis of heterocyclic alkaloids, including piperidines, quinolizidines, indolizidines, tropinones, and homotropinones, using the intramolecular Mannich cyclization reaction.

Funding

This work was supported by grants from the National Institutes of General Medical Sciences and Temple University.

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