An efficient copper-catalyzed synthesis of 2-mercaptobenzothiazole through S-arylation/heterocyclization of 2-haloaniline with potassium xanthate

ABSTRACT

A mild and efficient methodology to produce 2-mercaptobenzothiazoles in DMF via ortho-haloaniline coupling with potassium O-ethyl dithiocarbonate catalyzed by copper without a ligand has been developed.

GRAPHICAL ABSTRACT

Keyword:

• 2-Mercaptobenzothiazole
• ortho-iodoaniline
• potassium O-ethyl dithiocarbonate
• copper-catalyzed synthesis

Funding

This work was supported by the National Natural Science Foundation of China (21362019) and the Inner Mongolia Natural Science Foundation of China (2012MS0204).