Novel selenium-containing acenaphtho[1,2-b]pyrrole derivatives: Synthesis and bioactivity

GRAPHICAL ABSTRACT

ABSTRACT

Seven novel selenium-containing acenaphtho[1,2-b]pyrrole derivatives were designed and synthesized and their cytotoxic effects were evaluated by the MTT tetrazolium dye assay. Two compounds presented good anticancer activities.

KEYWORDS:

• Selenium
• acenaphtho[1,2-b]pyrrole
• cytotoxicity
• cancer

Acknowledgment

The authors would like to thank Professor Zhong Li, from East China University of Science and Technology, for his help and valuable suggestions.

Funding

This work was financially supported by the Shandong Wego Pharmaceutical Co. Limited.