![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
GRAPHICAL ABSTRACT
Abstract
A series of chloroalkyl- and chlorobenzyl-aminobis(methylenephosphonic acids) has been prepared by the interaction of the corresponding chloroalkylamines or chlorobenzylamines with two equivalents each of formaldehyde and phosphorous acid in the presence of hydrochloric acid. Attempts to prepare bromoalkyl analogues gave only the chloro derivatives, resulting from halogen exchange. Compounds were characterized by carbon-13 NMR spectroscopy and fast atom bombardment mass spectrometry for which the major fragmentation pathways are reported. Preliminary screening has not revealed significant biological activity.