Zwitterionic Ligands Bound to Cdse/Zns Quantum Dots Prevent Adhesion to Mammalian Cells

Ryan F. LandisDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts01003, USA

Rui TangDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts01003, USA

Singyuk HouDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts01003, USA

Mahdieh YazdaniDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts01003, USA

Yiwei LeeDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts01003, USA

Vincent M. RotelloDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts01003, USACorrespondence[email protected]

GRAPHICAL ABSTRACT

Abstract

Zwitterionic materials are useful tools in material science and biology as they provide high water solubility while preventing nonspecific interactions. Quantum dots (QDs) functionalized with zwitterionic and quaternary ammonium ligands were synthesized to investigate their interactions with the outer membrane of HeLa cells. Quaternary ammonium functionalized quantum dots adhered strongly to the cell surface while zwitterionic QDs had no cell adhesion. These results demonstrate that future noninteracting nanoparticles based on this design are possible.

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Zwitterionic Ligands Bound to Cdse/Zns Quantum Dots Prevent Adhesion to Mammalian Cells

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Zwitterionic Ligands Bound to Cdse/Zns Quantum Dots Prevent Adhesion to Mammalian Cells

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