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GRAPHICAL ABSTRACT
ABSTRACT
Precolumn chiral derivatization of fluorinated aminophosphonic acids was successfully accomplished with standard reagent consisting of N-acetyl-L-cysteine and o-phthaldialdehyde. Thus formed diastereomeric isoindole derivatives were characterized by means of ultraviolet- and mass-spectroscopic techniques. The chromatographic behavior of diastereomeric isoindole derivatives has been studied on different reverse phase columns. Operationally simple chromatographic analysis enabled the selective discrimination of fluorinated aminophosphonic acid enantiomers.
Funding
This study was financially supported by Ukrainian National Academy of Sciences (Grant 07-03-15).