A simple and efficient approach to the synthesis of 1-phosphonated 5-amino-1-H-[1,2,4]-triazole from N-functionalized imidates

Dhiab JabliLaboratory of Organic Chemistry, Department of Chemistry, Faculty of Sciences, El Manar University, Tunis, TunisiaCorrespondence[email protected]

Khaireddine DridiLaboratory of Organic Chemistry, Department of Chemistry, Faculty of Sciences, El Manar University, Tunis, Tunisia;Department of Chemistry, College of Sciences and Arts, Qassim University, Kingdom of Saudi Arabia

Mohamed Lotfi EfritLaboratory of Organic Chemistry, Department of Chemistry, Faculty of Sciences, El Manar University, Tunis, Tunisia

ABSTRACT

In this study, we describe a new and easy synthetic approach to variously substituted triazoles based on the reaction of imidates with phosphorylated hydrazine in good yields. A general mechanism of the reactions was also proposed. Characterization of the products was carried out by several analytical and spectroscopic tools including infrared and nuclear magnetic resonance spectroscopies (¹H, ¹³C NMR, ³¹P NMR).

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A simple and efficient approach to the synthesis of 1-phosphonated 5-amino-1-H-[1,2,4]-triazole from N-functionalized imidates

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A simple and efficient approach to the synthesis of 1-phosphonated 5-amino-1-H-[1,2,4]-triazole from N-functionalized imidates

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