N-Isocyaniminotriphenylphosphorane (Ph₃PNNC) as a metal-free catalyst for the synthesis of functionalized isoindoline-1-ones

GRAPHICAL ABSTRACT

ABSTRACT

A novel application in the field of N-isocyaniminotriphenylphosphorane (Ph₃PNNC) chemistry has been introduced in this work. A series of substituted isoindolin-1-one ring systems has been successfully synthesized through a novel and efficient multicomponent reaction of methyl 2-formylbenzoate and primary amines in the presence of N-isocyaniminotriphenylphosphorane (Ph₃PNNC) as a catalyst. This one-pot three component reaction (3-CR) gives high yield using N-isocyaniminotriphenylphosphorane (Ph₃PNNC) as a metal-free catalyst under mild conditions.

KEYWORDS:

• N-Isocyaniminotriph-enylphosphorane (Ph₃PNNC)
• isoindolin-1-one
• metal-free catalyst
• multicomponent reaction
• methyl 2-formylbenzoate

Funding

This work is funded by 2015 Yeungnam University Research Grant.