Synthesis, characterization, crystal structure, and antibacterial evaluation of Ni (II) complex with new dithiophosphorus compound

GRAPHICAL ABSTRACT

ABSTRACT

The reaction of 2,4-bis (4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (Lawesson^’s reagent) with phenylethylamine produced [H₃NCH₂CH₂C₆H₅]⁺ [(C₆H₅CH₂CH₂NH)(p C₆H₄OMe)PS₂]⁻ (1). Furthermore, reaction of 1 with NiCl₂ in dry methanol led to the novel complex 2. The compounds were characterized by ¹H and ³¹P NMR, IR spectroscopy, and elemental analysis. A single crystal X-ray structure of complex 2 showed that the nickel complex is square planar. The complex formed a supramolecular structure via intermolecular S1…H7B and O1…H2N2 hydrogen bonds. The X-ray crystallography of complex showed [R²₂](18) and R⁴₄(18) motifs in the monomers were connected to each other via S1…H7B, O1…H2N2 hydrogen bonds with donor–acceptor distance of 2.89 and 2.51 Å, respectively. The new compounds were additionally tested in view of their antibacterial properties.

KEYWORDS:

• Dithiophosphorus
• Ni (II) complex
• crystal structure
• hydrogen bonding
• antibacterial activity

Acknowledgment

We are grateful to Islamic Azad University of Tehran, Science and Research Branch for supporting this research.