Microwave-assisted neat synthesis of α-aminophosphonate/phosphinate derivatives of 2-(2-aminophenyl)benzothiazole as potent antimicrobial and antioxidant agents

GRAPHICAL ABSTRACT

ABSTRACT

A series of diethyl/ethylphenyl {2-(benzo[d]thiazol-2-yl)phenylamino}phosphonates and phosphinates were synthesized under microwave irradiation and neat conditions via Kabachnik-Fields reaction in high yields (80%–93%). The compounds were screened for antimicrobial and antioxidant properties. A few compounds showed effective antibacterial and antifungal activities at MIC value 12.5 μg/mL as compared with the standard at MIC value 6.25 μg/mL.

KEYWORDS:

• 2-(2-Aminophenyl) benzothiazole
• neat conditions
• microwave irradiation
• Kabachnik-Fields reaction
• antimicrobial and antioxidant activity

Acknowledgments

The author, SK. Thaslim Basha, expresses thanks to UGC for awarding SRF.