Simple, rapid, and clean condensation of sulfonamide and maleic anhydride derivatives: Synthesis of novel 1H- Pyrrole-2,5-diones under heterogeneous conditions

GRAPHICAL ABSTRACT

ABSTRACT

H₆P₂W₁₈O₆₂ is used as an efficient catalyst for the synthesis of novel N-substituted sulfonyl maleimides (1H-Pyrrole-2,5-diones) via the condensation of sulfonamide and maleic anhydride derivatives. The Dawson heteropolyacid was used with a catalytic amount of 2 mmol% in acetonitrile at reflux. The reuse of H₆P₂W₁₈O₆₂ as heterogeneous catalyst several times without decrease in their activity, short reaction times, easy isolation of desired products with good to excellent yields shows the advantages of this novel methodology.

KEYWORDS:

• Sulfonamide
• maleimides (1H-Pyrrole-2,5-diones)
• Dawson heteropolyacid
• heterogeneous conditions
• catalyst reuse