(O,O-Dibutyl)-O-1-trifluoromethyl-2,2,2-trifluoroethyl phosphate (BFP): A selective inhibitor of mouse plasma carboxylesterase

GRAPHICAL ABSTRACT

ABSTRACT

A comparative analysis of acetylcholinesterase, butyrylcholinesterase, and carboxylesterase inhibition by (O,O-dibutyl)-O-1-trifluoromethyl-2,2,2-trifluoroethyl phosphate (BFP) in vitro in hemolysed mouse blood preparations and in vivo 1 h after i.p. injections of BFP at increasing doses was performed. BFP was shown to be an effective and selective mouse blood CaE inhibitor both in vitro and in vivo. The time course of blood CaE inhibition demonstrated deep inhibition during 6–7 h.

KEYWORDS:

• (O,O-dibutyl)-O-1-trifluoromethyl-2,2,2-trifluoroethyl phosphate
• carboxylesterase
• selective inhibitor
• mouse blood

Funding

Supported by Russian Academy of Science Program “Medicinal Chemistry” and Russian Foundation for Basic Research (Grant No. 14-03-01063).