Synthesis and antituberculosis activity of some phosphorus containing glycolipids on the basis of glucuronic acid

Yevgeny Izmest'evA.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russian Federation

Olga AndreevaA.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russian Federation

Radmila SharipovaA.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russian Federation

Bulat GarifullinA.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russian Federation

Irina StrobykinaA.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russian Federation

Marionella KravchenkoUral Research Institute for Phthisiopulmonology, Ministry of Health Protection of the Russian Federation, Yekaterinburg, Russian Federation

Vladimir KataevA.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russian FederationCorrespondence[email protected]

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GRAPHICAL ABSTRACT

ABSTRACT

Several phosphorus containing glycolipids on the basis of glucuronic acid have been synthesized. The target compounds inhibited the in vitro growth of M. tuberculosis at MIC values of 12.5 µg/mL.

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Funding

The study was performed under the financial support of the Russian Science Foundation (grant No. 14-50-00014).

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Synthesis and antituberculosis activity of some phosphorus containing glycolipids on the basis of glucuronic acid

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Synthesis and antituberculosis activity of some phosphorus containing glycolipids on the basis of glucuronic acid

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