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Original Articles

Synthesis, structure, and biological activity of dicarboxylate phosphabetaines

, , , , , , , , & show all
Pages 1633-1636 | Received 04 Aug 2016, Accepted 09 Aug 2016, Published online: 19 Aug 2016
 

GRAPHICAL ABSTRACT

ABSTRACT

New stable dicarboxylate phosphabetaines were synthesized by the phosphorylation of a series of unsaturated carboxylic acids. Interaction of 3-(diphenylphosphonio)propionic acid with unsaturated monocarboxylic acids leads to the formation of stable dicarboxylate phosphabetaines 1–7. The structure of the isolated compounds was determined by IR and NMR spectroscopy, X-ray single crystal diffraction studies, and elemental analysis. Their thermal stability was studied by simultaneous thermogravimetry and differential scanning calorimetry. All of the synthesized compounds were tested for their antibacterial and anti-Candida activity.

Funding

This work was funded by the subsidy allocated to Kazan Federal University for the state assignment in the sphere of scientific activities.

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