Synthesis of novel thiazolidine-4-one derivatives and their anticancer activity

GRAPHICAL ABSTRACT

ABSTRACT

This paper describes the synthesis of a novel series of 1,3-thiazolidine-4-ones 6a-n by cycloaddition reaction of N-aryl-N'-acyl thioureas 4a-k with acetylenic esters 5a-b under microwave irradiation and solvent free conditions. Our method, compared to conventional heating conditions has the benefit of higher reaction yield and shorter reaction times. Structural confirmation and characterization of products based on the analytical, chemical, and spectral analysis was confirmed. Cellular investigations showed that the target synthesized thiazolidine-4-ones are toxic and could be used as anticancer agents for MKN-45 gastric adenocarcinoma cells.

KEYWORDS:

• Thiazolidine-4-one
• N-aryl-N'-acyl thioureas
• microwave
• toxicity investigations and cancer cells

Acknowledgments

We acknowledge the useful suggestions made by Professor Douglas Fry of SAFC, USA.

Funding

The partial support of this research by the Research Committee of the University of Guilan and Tonekabon Branch, Islamic Azad University is gratefully acknowledged.