ABSTRACT
A new and efficient protocol for the P, O chelate Pd(II)/AgNO3 cocatalyzed oxidative homocoupling reaction of aromatic terminal alkynes in the synthesis of symmetrical 1,4-disubstituted-1,3-diynes was described in aqueous media under ambient atmosphere. The results showed that both NEt3 and THF/H2O (in 4:1 proportion) played crucial roles in the reaction. In contrast, this protocol employs a low palladium(II) complex loading and AgNO3 as cocatalyst to obtain the homocoupled products in moderate to good yields.
Acknowledgments
The authors thank the National Natural Science Foundation of China (No: 21363026) and the Scientific and Technological Landing Project of Higher Education of Jiangxi Province (No: KJLD13091).