Asparagusic acid derivatives and their cytotoxic platinum(II) complexes

Jana HildebrandtInstitute of Inorganic and Analytical Chemistry, Friedrich-Schiller UniversityJena, Germany;Department for Gynecology, Jena University Hospital - Friedrich-Schiller UniversityJena, Germany

Tobias NikschInstitute of Inorganic and Analytical Chemistry, Friedrich-Schiller UniversityJena, Germany

Ralf TrautweinInstitute of Inorganic and Analytical Chemistry, Friedrich-Schiller UniversityJena, Germany

Norman HäfnerDepartment for Gynecology, Jena University Hospital - Friedrich-Schiller UniversityJena, Germany

Helmar GörlsInstitute of Inorganic and Analytical Chemistry, Friedrich-Schiller UniversityJena, Germany

Marie-Christin BarthInstitute of Inorganic and Analytical Chemistry, Friedrich-Schiller UniversityJena, Germany

Matthias DürstDepartment for Gynecology, Jena University Hospital - Friedrich-Schiller UniversityJena, Germany

Ingo B. RunnebaumDepartment for Gynecology, Jena University Hospital - Friedrich-Schiller UniversityJena, Germany

Wolfgang WeigandInstitute of Inorganic and Analytical Chemistry, Friedrich-Schiller UniversityJena, GermanyCorrespondence[email protected]

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GRAPHICAL ABSTRACT

ABSTRACT

This work presents platinum(II) compounds with asparagusic acid and derivatives as ligands. Examples of these derivatives were characterized using X-ray diffraction methods and the cytotoxic activity of corresponding platinum(II) complexes was measured in vitro against ovarian cancer cell lines SKOV3 and A2780 and their specially prepared cisplatin-resistant analogues.

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