Convenient synthesis of α-diarylmethylphosphonates by HOTf catalyzed Friedel-Crafts arylation of α-aryl α-hydroxyphosphonates

GRAPHICAL ABSTRACT

ABSTRACT

We report a convenient catalytic Friedel-Crafts arylation of α-aryl α-hydroxyphosphonates with various (hetero)aromatic compounds. HOTf (trifluoromethanesulfonic acid) is identified to be the best Brønsted acid catalyst, and the desired α-diarylmethylphosphonates were obtained in up to 41–95% yield.

KEYWORDS:

• Alcohols
• Friedel-Crafts arylation
• α-Diarylmethylphosphonates
• homogeneous catalysis
• α-hydroxyphosphonates

Funding

The financial support from Chengdu University New Faculty Start-up Funding (No. 2081916045) and the Open Project Program of Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province (No. ARRLKF16-03) is highly appreciated.

Supplementary material

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