Choline chloride based eutectic solvent for the efficient synthesis of 2-amino-4H-chromen-4-yl phosphonate derivatives via multicomponent reaction under mild conditions

ABSTRACT

Synthesis of 2-amino-4H-chromen-4-ylphosphonate derivatives has been accomplished by the one-pot three-component reaction of salicylaldehyde, malononitrile/ethylcyanoacetate and dialkyl phosphites in the presence of reusable deep eutectic solvent (DES) under mild conditions. The advantages of this method are mild reaction conditions, simple work-up procedure, use of DES as a green solvent and an economical protocol for the preparation of important biologically active phosphorus-containing compounds.

GRAPHICAL ABSTRACT

KEYWORDS:

• Multicomponent reaction
• 2-amino-4H-chromen-4-ylphosphonate derivatives
• deep eutectic solvent
• one-pot synthesis
• green chemistry

Acknowledgement

This work was supported by a Research Grant of Pukyoung National University (2017).