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ABSTRACT
The synthesis of new α-aminophosphonates 4a-j (diethyl((dialkoxyphosphoryl)(phenyl)methyl)phosphoramidates) were achieved through a one pot simple and efficient method from the three-component condensation reaction (Kabachnik-Fields reaction) of diethyl phosphoramidate, aryl salicylaldehydes, and dialkyl phosphite by using microwave irradiation under solvent-free and catalyst-free conditions in good to excellent yields and short reaction times. The structures of the novel products were established by IR, 1H, 13C & 31P-NMR and Mass spectroscopy. All the synthesized compounds were screened their antimicrobial activity.
GRAPHICAL ABSTRACT
Acknowledgments
The authors express thanks to Prof. C. Devendranath Reddy, Department of Chemistry, Sri Venkateswara University, Tirupati, for his helpful discussions, acknowledge the DST-SERB, New Delhi, India for providing financial support through the Project File No: SB/S1/OC-96/2013, dated: 05-11-2014. The corresponding author Prof. C. Suresh Reddy, being an associate member of Institute of Food Security and Sustainable Agriculture, University Malaysia Kelantan, Jeli Campus, Malaysia expresses his sincere thanks to University Malaysia Kelantan for their timely encouragement in our research work.
