Synthesis, spectral characterization and antibacterial activity of O, O’-dialkyl and alkylene dithiophosphatogold (III)dichloride; crystal structure of [S₂POCMe₂CMe₂O]AuCl₂

Abstract

O, O’-Dialkyl and alkylene dithiophosphatogold (III)dichloride complexes of the type [(RO)₂PS₂]AuCl₂ and [S₂POGO]AuCl₂, where R = Et, nPr, iPr, iBu, Ph, cyclohexyl and cyclopentyl, where G = CMe₂CMe₂-, have been synthesized in 80-90% yields by reaction of the corresponding acid or sodium salts of the appropriate dithiophosphoric acids in 1:1 ratio with gold (III) chloride in dry dichloromethane at room temperature. The compounds have been characterized by elemental analyses, IR and (¹H, ^l3C, and ³¹P) NMR. The crystal structure of [S₂POCMe₂CMe₂O]AuCl₂, was determined. These new complexes have shown their growth inhibiting potential against various bacterial strains with moderate to good activity.

Graphical Abstract

Keywords:

• Gold dithiophosphates
• cyclic and open chain gold (III) dithiophosphates
• crystal structure of O
• O’-1,1,2,2-tetramethylethylene dithiophosphatogold (III)dichloride

Acknowledgments

We thank the Obama Sing fellowship program, Michigan State University, Chemistry Department and Faculty of Engineering in Alabama A&M University for support of this research.

Disclosure statement

No potential conflict of interest was reported by the authors.

Table 1. Crystal data and structure refinement for O, O’-1,1,2,2-tetramethyl ethylene dithiophosphatogold (III)dichloride.