Synthesis, structure and bioactivity of novel carboxylate phosphabetaine derivatives with long alkyl chains

Abstract

The purpose of the present study was to investigate the antimicrobial activity of novel phosphonium salts: (2-carboxyethyl)(alkyl)diphenylphosphonium iodides and bromides 1–8 and carboxylate phosphabetaines: 3-(alkyldiphenylphosphonio)propanoates 9–16. The in vitro microbiological activity of the synthesized phosphonium compounds against gram-positive, gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. The synthesized phosphonium salts and phosphabetaines showed a high antibacterial and antimycotic activity against human and animal pathogenic microflora. Every newly synthesized compound was characterized by elemental analyses, IR, ¹H NMR, ³¹P NMR spectral studies. The thermal stability was studied by synchronous thermogravimetry and differential scanning calorimetry (TG/DSC).

Graphical Abstract

Keywords:

• Phosphonium salts
• phosphabetaines
• long alkyl chain
• antimicrobial activity

Acknowledgements

The work is performed according to the Russian Government Program of Competitive Growth of Kazan Federal University