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Original Articles

Novel advances in the synthesis of bisphosphonates, containing heterocyclic and macrocyclic structure

, , , &
Pages 482-486 | Received 30 Sep 2018, Accepted 15 Oct 2018, Published online: 17 Feb 2019
 

Abstract

Herein we describe our recent advances in the synthesis of new bisphosphonates, containing adenosines, adenine moiety as well as reactive aminoacetal fragment and calix[4]resorcinols framework. For the synthesis of these compounds we used three main approaches: Michael addition of nucleophilic amines (adenosines, adenines and aminoacetaldehyde) to (tetraethyl)ethenylidene-1,1-bisphosphonate and tetrakis(trimethylsilyl)ethenylidene-1,1-bisphosphonate); acid catalyzed condensation of bisphosphonic acid derivatives, containing acetal group with polyphenols; formation of onium salts of bisphosphonic acids with adenosine and aminomethylated calix[4]resorcinols.

GRAPHICAL ABSTRACT

Additional information

Funding

The reported research was funded by Russian Foundation for Basic Research and the government of the Republic of Tatarstan, grant № 18-43-160004.

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