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Short Communication

Electrochemical C-H phosphonation of caffeine

ORCID Icon, ORCID Icon & ORCID Icon
Pages 343-344 | Received 14 Sep 2018, Accepted 28 Sep 2018, Published online: 19 Jan 2019
 

Abstract

A convenient oxidant-free phosphorylation of caffeine by dialkyl-H-phosphonates under electrochemical mild conditions in the presence of metal catalyst is proposed. Silver salts, nickel and palladium complexes were tested as catalysts.This method allows to obtain the dialkylphosphonate derivatives of caffeine in good yields (up to 80%).

Graphical Abstract

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