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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 194, 2019 - Issue 11
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Original Articles

Polyethylene glycol (PEG-400): An efficient one-pot green synthesis and anti-viral activity of novel α-diaminophosphonates

Harika PatnalaDepartment of Chemistry, Andhra Loyola Institute of Engineering and Technology, Vijayawada, Andhra Pradesh, India;
,
Hanna S. AbboDepartment of Chemistry, University of Basrah, Basrah, Iraq; ;Department of Chemistry, University of the Western Cape, Bellville, Cape Town, South Africa;
,
Krishna Murthy PotlaDepartment of Chemistry, Bapatla Engineering College, Acharya Nagarjuna University Post Graduate Research Centre, Bapatla, Andhra Pradesh, India;
,
Salam J. J. TitinchiDepartment of Chemistry, University of the Western Cape, Bellville, Cape Town, South Africa; ;Department of Chemistry, University of Basrah, Basrah, Iraq; Correspondence[email protected] [email protected]
ORCID Iconhttp://orcid.org/0000-0002-5785-5021
ORCID Icon &
Sampath ChinnamDepartment of Chemistry, B.M.S. College of Engineering, Bengaluru, Karnataka, IndiaCorrespondence[email protected] [email protected]
ORCID Iconhttp://orcid.org/0000-0002-5334-9076
ORCID Icon
Pages 1035-1039 | Received 24 Jan 2019, Accepted 10 Mar 2019, Published online: 13 Apr 2019
 
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Abstract

An efficient and eco-friendly protocol has been accomplished for a series of novel α-diaminophosphonates by a one-pot, three-component system via Kabachnik-Fields reaction of 4,4′-methylenedianiline, a variety of aryl/heteroaryl aldehydes and diphenylphosphite employing polyethylene glycol (PEG-400) as a green solvent at 80 °C. All products were obtained in good to excellent yields (80–95%). The identity of the new synthesized compounds was confirmed by IR, 1H, 13C, and 31P NMR, LC-MS and elemental analysis. In vivo anti-viral activity was evaluated against tobacco mosaic virus (TMV). Compounds 4b, 4c, 4j and 4k exhibited the highest anti-viral activities against tobacco mosaic virus (TMV) when compared with the standard drug ningnanmycin.

Graphical Abstract

Acknowledgements

The authors are grateful to CKS Pharma Labs (P) Ltd., Vedadri, Krishna District, Jaggayyapeta, Andhra Pradesh, India for the assistance.

Disclosure statement

There are no potential conflict of interest disclosed by the authors.

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