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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 194, 2019 - Issue 11
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Original Articles

Multicomponent one-pot synthesis of (dihydro-1H-benzo[d]imidazole) phosphonate

José Luis Castrejon-FloresUnidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Ciudad de México, México; View further author information
,
Oscar Ernesto Guevara-MorenoUnidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Ciudad de México, México; View further author information
,
Raúl Ricardo Díaz-ContrerasUnidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Ciudad de México, México; View further author information
,
Atilano Gutiérrez-CarrilloDepartamento de Química, División de Ciencias Básicas e Ingeniería, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, México; View further author information
,
Marco Franco-PérezDepartamento de Física y Química Teórica, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, MéxicoView further author information
,
Galdina Vanessa Suárez-MorenoUnidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Ciudad de México, México; Correspondence[email protected] [email protected]
View further author information
&
Angel Zamudio-MedinaUnidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Ciudad de México, México; Correspondence[email protected] [email protected]
View further author information
 show all
Pages 1062-1066 | Received 06 Nov 2018, Accepted 31 Mar 2019, Published online: 20 Apr 2019
 
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Abstract

We present a multicomponent reaction strategy to synthesize a (dihydro-1H-benzo[d]imidazole)phosphonate family of compounds, using benzimidazoles, diethyl chlorophosphate and aliphatic amines as starting reactants. Giving its simplicity, our procedure involves reaction times of only few hours and avoid the usage of any catalyst agent. All the newly synthesized compounds were characterized by Nuclear Magnetic Resonance spectroscopy (1H, 13C and 31P) and mass spectrometry by the DART method.

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Additional information

Funding

A. Zamudio thanks Secretariat for Instituto Politécnico Nacional (SIP-IPN), Granting 20161237 for financial support.

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