H₆P₂W₁₈O₆₂·14H₂O as an efficient catalyst for the green synthesis of α-aminophosphonates from α-amino acids

Abstract

A simple, efficient and eco-friendly protocol has been described for the synthesis of α-aminophosphonates via Kabachnik-Fields reaction, catalyzed by H₆P₂W₁₈O₆₂·14H₂O as a reusable catalyst. The reaction was realized by condensation of amino acids, various aromatic aldehydes and triethylphosphite under solvent-free conditions, the corresponding α-aminophosphonates were formed in good yields. All the new products were characterized by IR, ¹H, ¹³C and ³¹P-NMR analyses. This method offers advantages such as simplicity workup with the green aspects, good yields and short reaction times.

Graphical Abstract

Keywords:

• α-Aminophosphonates
• Kabachnik-Field reaction
• amino acids
• H₆P₂W₁₈O₆₂·14H₂O catalyst
• solvent-free conditions

Acknowledgments

The authors are grateful to General Directorate for Scientific Research and Technological Development (DG-RSDT), Algerian Ministry of Scientific Research.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Scheme 2. Role of catalyst (HPAs).

Scheme 1. The model reaction to optimize conditions (3a).