Two possible ways to combine boron and gadolinium for Gd-guided BNCT. A concept

Abstract

Two ways of synthesis of theragnostic compounds for Gd-guided boron neutron capture therapy of cancer are proposed. The first way is based on modification of DO3A ligand, which a capable to form stable complexes with gadolinium, with attachment of boron-containing moieties and additional functional groups which can be used for conjugation with various biomacromolecules. The second way is based on the introduction of additional chelating groups into a boron-containing moiety—carborane-based ligand. It is expected that this will significantly improve the stability of the gadolinium bis(dicarbollide) complexes.

GRAPHICAL ABSTRACT

Keywords:

• BNCT
• gadolinium
• carboranes
• metallacarboranes

Additional information

Funding

This work was supported by Grant of the President of the Russian Federation for Young PhD Researchers (MК-910.2019.3), Russian Foundation for Basic Research (19-53-50001), and Ministry of Science and Higher Education of the Russian Federation.