Design, synthesis, and herbicidal activity of novel pyrimidine derivatives containing 1,2,4-triazole

Abstract

A facile approach for the synthesis of pyrimidine derivatives containing 1,2,4-triazole moiety via the reaction of substituted 2-phenoxypropane hydrazide with ethyl-N-(5-cyano-2-alkylthio-5-cyano-6-methylthiopyrimidin-4-yl) formimidate in refluxing 2-methoxyethanol is reported. The structures of the title compounds were identified by ¹H NMR, ¹³C NMR, and HRMS. The configuration of compound 5a was confirmed by X-ray crystallography analysis. The preliminary herbicidal test indicated that some of the target compounds exhibited good inhibition activities against Brassica napus (rape) and Echinochloa crusgalli (barnyard grass).

GRAPHICAL ABSTRACT

Keywords:

• Pyrimidine derivatives containing 1,2,4-triazole
• synthesis
• preliminary herbicidal test
• inhibition activities

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (Nos. 21562026, 21762025).